What is Cushing’s Syndrome? What are the symptoms and treatments?

What is Cushing's Syndrome? What are the symptoms and treatments?

Cushing’s syndrome is the result of excessive production of cortisol hormone in the body. Cortisol is a hormone normally made by the adrenal glands and is necessary for life. This hormone allows one to respond to stressful situations such as sickness. Almost all body tissues are affected. The production of too much cortisol in the body is called Cushing’s syndrome regardless of its cause. What is the indication of Cushing’s syndrome which is not known in our country?


Cushing’s syndrome manifests itself in a wide range of patients, from mild to severe in each patient. The most common symptom in adults is weight gain and is especially evident in the body. Other common symptoms include hypertension, memory problems, loss of attention and concentration.

Excessive elevation of cortisol hormone causes protein loss in body tissues. Protein loss results in muscle weakness. Fat deposits are seen in various parts of the body. Particularly in the end of the accumulation of the face and the accumulation of the shoulder between the end result is called the bufalo kamburu.






Depressive mood

Emotional loss of control

Increase in Civilizations

Percentage of redness


Easy breaking in bones

Excessive thirst

Frequent outings

Height in blood sugar levels

Obesity as a result of excessive weight gain

Recurrent infections

Thinning and easy browning

Pink or purple cracks in the abdomen, hip, chest and crown

Delay in wound and infection healing

Excessive hairiness in women

Irregular period

Decrease in sexual desire

Loss of erectile function in males

Fertility decline

Growth in children can be listed as growth.


The most common cause of Cushing’s syndrome is long-term and high-dose use of steroid-containing drugs. After organ transplants of these drugs, it may be necessary to use them at high doses in the treatment of disorders such as lupus or rheumatoid arthritis. Cream-like steroids used for asthma inhalers or urticaria do not cause Cushing syndrome because they are in low doses.

Other causes of the disease;

Tumors of the pituitary gland in the brain that cause high amounts of ACTH hormone production

Some tumors of the lung, pancreas and thyroid gland

It is listed as overworked or tumors of the adrenal gland.

Some pituitary tumors produce a hormone called adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands and causes excessive cortisol production. The condition that occurs in this way is called Cushing’s disease. These pituitary tumors are usually well-behaved and usually do not cause cancer. Some individuals are predisposed to tumoral formations that genetically cause Cushing syndrome.


Your doctor will ask you for detailed questions about your illness first. He then performs a detailed physical examination. If he suspects Cushing’s syndrome, he asks you to take some tests.

Free cortisol level in 24 hour urine: This test is based on the measurement of free cortisol levels by accumulating urine for 24 hours.

Dexamethasone suppression test: In this test you are asked to take a pill containing dexamethasone at 11 o’clock at night. The next morning blood cortisol level is checked.

Midnight salivary cortisol level measurement: This test is a midnight test. The level of saliva cortisol is measured.

As a result of the tests done, Cushing’s syndrome is diagnosed and advanced examinations such as MR imaging of the kidney are performed to find the cause.


In treatments for Cushing’s syndrome, the goal is to lower the high cortisol levels in our bodies. The treatment is planned for the cause of the disease.

If the underlying cause of Cushing’s syndrome is the long-term use of corticosteroids, your doctor may consider reducing the dosage of the drug for a period of time.

If the disease is caused by a tumor, surgical treatment options are evaluated.

If tumoral tissue is not surgically removed, radiotherapy is applied.

If radiotherapy is not enough, drugs that suppress cortisol production are used.

If none of these treatment options are appropriate or effective, your doctor may recommend surgical removal of the adrenal gland. This procedure improves cortisone production in extreme amounts, but requires some lifetime use of medicines.

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